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21% of Parents more than Double the Dose

Pain Medications are the single most frequent cause of Pediatric Death reported to the US Poison Control from 2011 – 2015

Dosing errors are the among the most common and most preventable causes of adverse drug events in children
84.4% of parents give their children the wrong dose of medication
The only oral dosing syringes offering
all recommended OTC dosing methods
EXACT CHILDS WEIGHT TO EXACT DRUG POTENCY
AGE RANGE FOR ALTERNATE DOSE MODE OR
    REVERIFICATION
VOLUME OR MG INDICIA FOR ALL ADDITIONAL
    DOSING MODES
Dose Directly
Dose Accurately™
Infants' Acetaminophen

160mg/5mL

Childrens' Acetaminophen

160mg/5mL

Infants' Ibuprofen

50mg/1.25mL

Childrens' Ibuprofen

100mg/5mL

Childrens' Diphenydramine

12.5mg/5mL

D2W Syringe
OTC Medication Errors
D2W Survey

Oral OTC Dispensers

Researchers have shown that only 30% of caregivers are able to demonstrate both an accurately measured and correct dose for their child.1 Generally over-the-counter (OTC) medications are considered safe, however they are the most frequently implicated pharmaceuticals involved in cases reported to the American Association of Poison Control Center’s National Poison Data System.2

Current dosing recommendations for OTC oral medications commonly specify a volume of medication for a weight or age range, rather than using the dosage strength of the medication specific to an individual patient weight. For example, the current Acetaminophen dosing regimen results with patients in a designated range receiving the same amount of medication, even though their individual weight may differ more than 45% (6-11lbs); and patients in different ranges receiving double the medication (40-80mg) despite having a difference in weight of 1lb, (11-12lbs).

1Simon, H. K., & Weinkle, D. A. (1997). Over-the-counter medications: do parents give what they intend to give?  Archives of pediatrics & adolescent medicine151(7), 654-656.

2Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Heard SE. 2007 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol (Phila). 2008; 46(10):927-1057.

3Tylenol® Infants and Children’s Dosing Information for Healthcare Professionals

4Adjusted for U.S. Market and mL dosing conformity – (adjusted from Dose-2-Weight Optimal Dose of 5.67 mg/lb. to 4.60 mg/lb.)     

Dose-2-Weight Syringe®

The patented Dose-2-Weight Syringe® is the next generation liquid medication dispenser. Each Dose-2-Weight Syringe® is calibrated to the dosage strength of a specific medication and marked with multiple correlated measurements. These measurements may include, among others, weight or other patient characteristic, medication dosage or volume of the medication. The enhanced multi-indicia display increases the overall safety and accuracy of administration, by providing the ability to intuitively correlate the unit dosage to a specific patient characteristic.

The Dose-2-Weight Syringe® eliminates the need to correlate a volume, unit dosage or patient feature from a medication package or other media to the delivery device. These features circumvent the procedures shown to be the primary cause of error during the preparation and administration of OTC liquid medications.

The Dose-2-Weight Syringe® provides un-matched safety and convenience during preparation and administration, while in parallel, providing ultra-precise dosing and visual reverification of the correct amount of medication for the specific patient.

Benefits:

  • Calibrated Measurements Indicia for Weight, Age, BSA and Volumetric Dosage
  • Ultra-Precise Dosing
  • Optional keyed tip paired to container closures or valve restrictions
  • Convenient
  • Calculation free
  • Lower incremental indicia
  • Easy to read markings
  • Ergonomic
  • Safe
  • CE/ISO/WHO/TUV certified

ORDERING INFORMATION

Dose-2-Weight Syringe®
Calibrated for specific medication

Three-part oral dispenser

  • Short or long tip barrel
  • Silicone O-ring plunger
  • No rubber, latex free
  • BPA free
  • 100% vision inspected calibration lines
  • Dishwasher safe, maintains print quality
  • CE registration
  • Multiple barrel and plunger colors available
Size Graduations Sterility Material Packaging Barrel
1, 2, 3, 5, 10, 20, 30, 50, 60 mL Weight: kg, lb

Age: mo, yr

Dosage: mg, mL

SA: ft2, m2

Sterile

Non-sterile

Barrel: PP

Plunger: HDPE

PE

Blister

Bulk

Round

INFANTS ACETAMINOPHEN

Current Dosing Schedule 1
Acetaminophen 160 mg/5mL
lb mL mg mg/lb
lb Current Current Current
6 1.25 40 6.67
7 1.25 40 5.71
8 1.25 40 5.00
9 1.25 40 4.44
10 1.25 40 4.00
11 1.25 40 3.64
12 2.5 80 6.67
13 2.5 80 6.15
14 2.5 80 5.71
15 2.5 80 5.33
16 2.5 80 5.00
17 2.5 80 4.71
18 3.75 120 6.67
19 3.75 120 6.32
20 3.75 120 6.00
21 3.75 120 5.71
22 3.75 120 5.45
23 5.0 120 5.22
24 5.0 160 6.67
25 5.0 160 6.40
26 5.0 160 6.15
27 5.0 160 5.93
28 5.0 160 5.71
29 5.0 160 5.52
30 5.0 160 5.33
31 5.0 160 5.16
32 5.0 160 5.00
33 5.0 160 4.85
34 5.0 160 4.71
35 5.0 160 4.57
Average: 5.48
Dose-2-Weight Schedule 2,3,4,5
Acetaminophen 160 mg/5mL
lb mL mg mg/lb
lb D2W D2W D2W
6 0.86 27.6 4.60
7 1.01 32.2 4.60
8 1.15 36.8 4.60
9 1.29 41.4 4.60
10 1.44 46.0 4.60
11 1.58 50.6 4.60
12 1.73 55.2 4.60
13 1.87 59.8 4.60
14 2.01 64.4 4.60
15 2.16 69.0 4.60
16 2.30 73.6 4.60
17 2.44 78.2 4.60
18 2.59 82.8 4.60
19 2.73 87.4 4.60
20 2.88 92.0 4.60
21 3.02 96.6 4.60
22 3.16 101.2 4.60
23 3.31 105.8 4.60
24 3.45 110.4 4.60
25 3.59 115.0 4.60
26 3.74 119.6 4.60
27 3.88 124.2 4.60
28 4.03 128.8 4.60
29 4.17 133.4 4.60
30 4.31 138.0 4.60
31 4.46 142.6 4.60
32 4.60 147.2 4.60
33 4.74 151.8 4.60
34 4.89 156.4 4.60
35 5.03 161.0 4.60
Average: 4.60

1] Tylenol® Infants and Children’s Dosing Information for Healthcare Professionals

2] Adjusted for U.S. Market and mL dosing conformity – (adjusted from Dose-2-Weight Optimal Dose of 5.67 mg/lb. to 4.60 mg/lb.)

3] US Food and Drug Administration – Over the counter Acetaminophen –Containing Drug Products in Children Background Package – Efficacy and Safety Studies published and reviewed at 4.53 mg/lb. to 6.80 mg/lb. Publish Studies mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

4] Boston University Fever Study –- Dosing at 4.53 mg/lb. to 6.80 mg/lb. Publish Studies mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

5] American Academy of Pediatric Endorses Weight Based Dosing – Recommended Dosing at 4.53 mg/lb. to 6.80 mg/lb. mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

CHILDRENS ACETAMINOPHEN

Today’s Dosing Schedule 1
Acetaminophen 160 mg/5mL
 lb mL mg mg/lb
lb Current Current Current
 36  7.5 240 6.67
37 7.5 240 6.49
38 7.5 240 6.32
39 7.5 240 6.15
40 7.5 240 6.00
41 7.5 240 5.85
42 7.5 240 5.71
43 7.5 240 5.58
44 7.5 240 5.45
45 7.5 240 5.33
46 7.5 240 5.22
47 7.5 240 5.11
48 10 320 6.67
49 10 320 6.53
50 10 320 6.40
51 10 320 6.27
52 10 320 6.15
53 10 320 6.04
54 10 320 5.93
55 10 320 5.82
56 10 320 5.71
57 10 320 5.61
58 10 320 5.52
59 10 320 5.42
Average: 5.92
Dose-2-Weight Schedule 2,3,4
Acetaminophen 160 mg/5mL
mL mg mg/lb
lb D2W D2W D2W
36 6.33 202.7 5.63
37 6.51 208.3 5.63
38 6.69 213.9 5.63
39 6.86 219.6 5.63
40 7.04 225.2 5.63
41 7.21 230.8 5.63
42 7.39 236.5 5.63
43 7.57 242.1 5.63
44 7.74 247.7 5.63
45 7.92 253.4 5.63
46 8.09 259.0 5.63
47 8.27 264.6 5.63
48 8.45 270.2 5.63
49 8.62 275.9 5.63
50 8.80 281.5 5.63
51 8.97 287.1 5.63
52 9.15 292.8 5.63
53 9.32 298.4 5.63
54 9.50 304.0 5.63
55 9.68 309.7 5.63
56 9.85 315.3 5.63
57 10.03 320.9 5.63
58 10.20 326.5 5.63
59 10.38 332.2 5.63
Average: 5.63

1] Tylenol® Infants and Children’s Dosing Information for Healthcare Professionals

2] Adjusted for U.S. Market and mL dosing conformity – (adjusted from Dose-2-Weight Optimal Dose of 5.67 mg/lb. to 5.63 mg/lb.)     

3] US Food and Drug Administration – Over the counter Acetaminophen –Containing Drug Products in Children Background Package – Efficacy and Safety Studies published and reviewed at 4.53 mg/lb. to 6.80 mg/lb. Publish Studies mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

4] Boston University Fever Study –- Dosing at 4.53 mg/lb. to 6.80 mg/lb. Publish Studies mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

5] American Academy of Pediatric Endorses Weight Based Dosing – Recommended Dosing at 4.53 mg/lb. to 6.80 mg/lb. mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

Ibuprofen Oral Dispensers

The original New Drug Application (NDA) for the approval of Children’s and Infants Ibuprofen recite safety and efficacy studies in fixed dosing of mg to kg. In fact, the majority of all clinical and pivotal safety studies in support of the approval of pediatric ibuprofen,1 such as the Boston Fever Study,2 were conducted and published also in fixed dosing, in either 5mg/kg or 10mg/kg. Moreover, the Food and Drug Administration’s Medical Reviewer’s final comments for pediatric approval, concluded the safety of OTC Ibuprofen in pediatric populations at the two doses tested, 5mg and 10mg.3

Collectively, the clinical data supported the approval of the NDA for Pediatric OTC Ibuprofen and the NDA continues to recite a fixed dose of either 5mg or 10mg/kg; depending on the patient’s baseline temperature or other condition.4 The American Association of Pediatrics also recommends a fixed dose of 10mg/kg,5 as well as other worldwide health agencies recommend a fixed dose to pediatric patient weight.

Contrary to all of the collective data, the current U.S. mL dosing regimen for Ibuprofen provides a highly variable dosing to these subtle pediatric patients. For example, current mL dosing provides the lowest weight and youngest patients (12lb at 6 months), the near maximum dose of 4.17mg/lb (9.2mg/kg) and the heaviest weight and oldest patient within that same range the lowest dose of 2.94mg/lb (6.48mg/kg). Additionally, the current regimen also provides extreme dosing variations, such as offering a 17lb patient 2.9mg/lb and an 18lb patient 4.2mg/lb, a percentage change of over 44% despite a one-pound difference in weight.

1 Simon, H. K., & Weinkle, D. A. (1997). Over-the-counter medications: do parents give what they intend to give?  Archives of pediatrics & adolescent medicine151(7), 654-656.

2 Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Heard SE. 2007 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol (Phila). 2008; 46(10):927-1057.

3 Adjusted for Current U.S. Market Dosing and mL conformity – (adjusted from 3.4 mg/lb. to 3.25 mg/lb)

Dose-2-Weight Syringe®

The patented Dose-2-Weight Syringe® is the next generation liquid medication dispenser. Each Dose-2-Weight Syringe® is calibrated to the dosage strength of a specific medication and marked with multiple correlated measurements. These measurements may include, among others, weight or other patient characteristic, medication dosage or volume of the medication. The enhanced multi-indicia display increases the overall safety and accuracy of administration, by providing the ability to intuitively correlate the unit dosage to a specific patient characteristic.

The Dose-2-Weight Syringe® eliminates the need to correlate a volume, unit dosage or patient feature from a medication package or other media to the delivery device. These features circumvent the procedures shown to be the primary cause of error during the preparation and administration of OTC liquid medications.

The Dose-2-Weight Syringe® provides un-matched safety and convenience during preparation and administration, while in parallel, providing ultra-precise dosing and visual reverification of the correct amount of medication for the specific patient.

Benefits:

  • Measurements for Weight, Age and Volumetric Dosage
  • Ultra-Precise Dosing
  • Convenient
  • Calculation free
  • Lower incremental indicia
  • Easy to read markings
  • Ergonomic
  • Safe
  • CE/ISO/WHO/TUV certified

ORDERING INFORMATION

Dose-2-Weight Syringe®
Calibrated for specific medication

Three-part oral dispenser

  • Short or long tip barrel
  • Silicone O-ring plunger
  • No rubber, latex free
  • BPA free
  • 100% vision inspected calibration lines
  • Dishwasher safe, maintains print quality
  • CE registration
  • Multiple barrel and plunger colors available
Size Graduations Sterility Material Packaging Barrel
1, 2, 3, 5, 10, 20, 30, 50, 60 mL Weight: kg, lb

Age: mo, yr

Dosage: mg, mL

SA: ft2, m2

Sterile

Non-sterile

Barrel: PP

Plunger: HDPE

PE

Blister

Bulk

Round

©Copyright 2017 by Asepsis Medical Technologies, LLC. Sarasota, FL.
All Rights Reserved, including the right of reproduction in whole or in part in any form

Dose-2-Weight Syringe® is a registered trademark of Asepsis Medical Technologies, LLC., and covered by one or more patents

including U.S. Patent 9,192,723 , U.S. Patent 9,302,050 , U.S. Patent 9,750,883 and Patents Pending

INFANTS IBUPROFEN

Current Dosing Schedule 1
Ibuprofen 40 mg/mL
mL mg mg/lb
lb Current Current Current
12.0 1.25 50 4.17
13.0 1.25 50 3.85
14.0 1.25 50 3.57
15.0 1.25 50 3.33
16.0 1.25 50 3.12
17.0 1.25 50 2.94
18.0 1.875 75 4.17
19.0 1.875 75 3.95
20.0 1.875 75 3.75
21.0 1.875 75 3.57
22.0 1.875 75 3.41
23.0 1.875 75 3.26
Average: 3.59
Dose-2-Weight Schedule 2,3,4
Ibuprofen 40 mg/mL
mL mg mg/lb
lb D2W D2W D2W
12.0 0.975 39.00 3.25
13.0 1.06 44.25 3.25
14.0  1.14  45.50 3.25
15.0 1.22 48.75 3.25
16.0 1.30 52.00 3.25
17.0 1.38 55.25 3.25
18.0 1.46 58.50 3.25
19.0 1.54 61.75 3.25
20.0 1.63 65.00 3.25
21.0 1.71 68.25 3.25
22.0 1.79 71.50 3.25
23.0 1.87 74.75 3.25
Average: 3.25

1] Motrin® Infants Dosing Charts for Children and Infants
2] Adjusted for Current U.S. Market Dosing and mL conformity – (adjusted from 3.4 mg/lb. to 3.25 mg/lb.)
3] US Food and Drug Administration – Medical Officer Review – Division of over the Counter Drug Products NDA 20-603, SE3-003 Children’s Motrin® – Efficacy and Safety Studies published and approved at 2.27 mg/lb. and second study at 4.54 mg/lb. Submission Study mid-point of 3.4 mg/lb.
4] Boston University Fever Study – Pivotal Safety Study used in support of approval of Children’s Motrin® – Dosing at 2.27 mg/lb. and also at 4.54 mg/lb. Study mid-point of 3.4 mg/lb.
Motrin® is a registered trademark of Johnson & Johnson.

CHILDRENS IBUPROFEN

Current Dosing Schedule 1
Ibuprofen 20 mg/mL
mL mg mg/lb
lb Current Current Current
24.0 5 100 4.17
25.0 5 100 4.00
26.0 5 100 3.85
27.0 5 100 3.70
28.0 5 100 3.57
29.0 5 100 3.45
30.0 5 100 3.33
31.0 5 100 3.23
32.0 5 100 3.13
33.0 5 100 3.03
34.0 5 100 2.94
35.0 5 100 2.86
36.0 7.5 150 4.17
37.0 7.5 150 4.05
38.0 7.5 150 3.95
39.0 7.5 150 3.85
40.0 7.5 150 3.75
41.0 7.5 150 3.66
42.0 7.5 150 3.57
43.0 7.5 150 3.49
44.0 7.5 150 3.41
45.0 7.5 150 3.33
46.0 7.5 150 3.26
47.0 7.5 150 3.19
48.0 10 200 4.17
49.0 10 200 4.08
50.0 10 200 4.00
51.0 10 200 3.92
52.0 10 200 3.85
53.0 10 200 3.77
54.0 10 200 3.70
55.0 10 200 3.64
56.0 10 200 3.57
57.0 10 200 3.51
58.0 10 200 3.45
59.0 10 200 3.39
Average: 3.61
Dose-2-Weight Schedule 2,3,4
Ibuprofen 20 mg/mL
mL mg mg/lb
lb D2W D2W D2W
24.0 4.08 81.6 3.40
25.0 4.25 85.0 3.40
26.0 4.42 88.4 3.40
27.0 4.59 91.8 3.40
28.0 4.76 95.2 3.40
29.0 4.93 98.6 3.40
30.0 5.10 102.0 3.40
31.0 5.27 105.4 3.40
32.0 5.44 108.8 3.40
33.0 5.61 112.2 3.40
34.0 5.78 115.6 3.40
35.0 5.95 119.0 3.4
36.0 6.12 122.4 3.40
37.0 6.29 125.8 3.40
38.0 6.46 129.2 3.40
39.0 6.63 132.6 3.40
40.0 6.80 136.0 3.40
41.0 6.97 139.4 3.40
42.0 7.14 142.8 3.40
43.0 7.31 146.2 3.40
44.0 7.48 149.6 3.40
45.0 7.65 153.0 3.40
46.0 7.82 156.4 3.40
47.0 7.99 159.8 3.40
48.0 8.16 163.2 3.40
49.0 8.33 166.6 3.40
50.0 8.50 170.0 3.40
51.0 8.67 173.4 3.40
52.0 8.84 176.8 3.40
53.0 9.01 180.2 3.40
54.0 9.18 183.6 3.40
55.0 9.35 187.0 3.40
56.0 9.52 190.4 3.40
57.0 9.69 193.8 3.40
58.0 9.86 197.2 3.40
59.0 10.03 200.6 3.40
Average: 3.40

1] Motrin® Infants Dosing Charts for Children and Infants

2] US Food and Drug Administration – Medical Officer Review – Division of over the Counter Drug Products NDA 20-603, SE3-003 Children’s Motrin® –  Efficacy and Safety Studies published and approved at 2.27 mg/lb. and second study at 4.54 mg/lb. Submission Study mid-point of 3.4 mg/lb.

3] Boston University Fever Study – Pivotal Safety Study used in support of approval of Children’s Motrin® Dosing at 2.27 mg/lb. and also at 4.54 mg/lb. Study mid-point of 3.4 mg/lb.

Motrin® is a registered trademark of Johnson & Johnson.