Acetaminophen - DOSE TO WEIGHT
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Acetaminophen

Infants and Children’s Acetaminophen

 

The American Academy of Pediatrics and U.S. FDA advisory panel, among others, recommend to dose acetaminophen to a child’s weight, and then age if the weight is not known. Conversely, no oral applicators included within acetaminophen products have a weight or age indicia.

 

Studies and statistical data continue to corroborate the leading causes of medication error during the administration of children’s and infants acetaminophen. The most common documented errors, stem from measuring confusion with the dosing device, and misunderstanding the product instruction label or dosing chart.

Further exacerbating these errors, is the current U.S. mL dosing regimen that provides highly variable dosing to sensitive pediatric patients. For example, current mL dosing provides the lowest weight and youngest patients (24lb at 24 months), the near maximum dose of 6.67mg/lb (14.69mg/kg) and the heaviest weight and oldest patient within the same range of (35lb at 36 months), receiving the lowest possible dose of 4.57mg/lb (10.08mg/kg). This dosing continues to be industry practice, although the original weight-based dosing schedule published in 1983, was intended to provide “increases in dose corresponding with incremental increases in weight”.

 

More importantly, the majority of the original safety and efficacy studies for the infants and children’s acetaminophen dosing regimen of 4.54mg/lb to 6.80mg/lb (10-15mg/kg), were conducted based upon a fixed unit dose to a specific patient weight (mg/kg), and not as a variable dose within this range.

 

The Dose-Weight Syringe® is specifically calibrated to administer a precise patient specific dose of acetaminophen between the U.S. FDA tentative final monograph, (TFM) and original safety and efficacy studies for the dosing approval of 4.53mg/lb to 6.80mg/lb (10-15mg/kg). More specifically, the Dose-Weight Syringe® is designed to deliver a highly precise enhanced dose to a specific patient characteristic, such as BMI, BSA, weight, or age within this range. The Dose-Weight Syringe® may be calibrated to deliver an optimal mid-point dose from the published safety and efficacy studies of infants and children’s acetaminophen, such as 5.67/mg/lb (12.5mg/kg), among other fixed doses within the recommended range.

Infants’
Acetaminophen

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Children’s Acetaminophen

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Acetaminophen Brochure

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Acetaminophen Oral Dispensers

Resarchers have shown that only 30% of caregivers are able to demonstrate both an accurately measured and correct dose for their child.1 Generally over-the-counter (OTC) medications are considered safe, however they are the most frequently implicated pharmaceuticals involved in cases reported to the American Association of Poison Control Center’s National Poison Data System.2

Current dosing recommendations for OTC oral medications commonly specify a volume of medication for a weight or age range, rather than using the dosage strength of the medication specific to an individual patient weight. This dosing regimen results with patients in a designated range receiving the same amount of medication, even though their individual weight may differ more than 45% (6-11lbs); and patients in different ranges receiving double the medication (40-80mg) despite having a difference in weight of 1lb, (11-12lbs).

1 Simon, H. K., & Weinkle, D. A. (1997). Over-the-counter medications: do parents give what they intend to give? Archives of pediatrics & adolescent medicine, 151(7), 654-656.

2 Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Heard SE. 2007 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol (Phila). 2008; 46(10):927-1057.

3 Tylenol® Infants and Children’s Dosing Information for Healthcare Professionals

4 Adjusted for U.S. Market and mL dosing conformity – (adjusted from Dose-2-Weight Optimal Dose of 5.67 mg/lb. to 4.60 mg/lb.)

Dose-2-Weight Syringe®

The patented Dose-2-Weight Syringe® is the next generation liquid medication dispenser. Each Dose-2-Weight Syringe® is calibrated to the dosage strength of a specific medication and marked with multiple correlated measurements. These measurements may include, among others, weight or other patient characteristic, medication dosage or volume of the medication. The enhanced multi-indicia display increases the overall safety and accuracy of administration, by providing the ability to intuitively correlate the unit dosage to a specific patient characteristic.

 

The Dose-2-Weight Syringe® eliminates the need to correlate a volume, unit dosage or patient feature from a medication package or other media to the delivery device. These features circumvent the procedures shown to be the primary cause of error during the preparation and administration of OTC liquid medications.

 

The Dose-2-Weight Syringe® provides un-matched safety and convenience during preparation and administration, while in parallel, providing ultra-precise dosing and visual reverification of the correct amount of medication for the specific patient.

Benefits:

  • Calibrated Measurements Indicia for Weight, Age, BSA and Volumetric Dosage
  • Ultra-Precise Dosing
  • Optional keyed tip paired to container closures or valve restrictions
  • Convenient
  • Calculation free
  • Lower incremental indicia
  • Easy to read markings
  • Ergonomic
  • Safe
  • CE/ISO/WHO/TUV certified

Ordering Information

Dose-2-Weight Syringe®
Calibrated for specific medication

Three-part oral dispenser

  • Short or long tip barrel
  • Silicone O-ring plunger
  • No rubber, latex free
  • BPA free
  • 100% vision inspected calibration lines
  • Dishwasher safe, maintains print quality
  • CE registration
  • Multiple barrel and plunger colors available
Size Graduations Sterility Material Packaging Barrel
1, 2, 3, 5, 10, 20, 30, 50, 60 mL Weight: kg, lb

Age: mo, yr

Dosage: mg, mL

SA: ft2, m2

Sterile

Non-sterile

Barrel: PP

Plunger: HDPE

PE

Blister

Bulk

Round

Press-in bottle adapter

Diameter Size Sterility Material Packaging
20, 24, 28mm Sterile/non-sterile LDPE Bulk

Custom Dispensing System

Our team of design engineers will work with your specific requirements to provide you a customized dispensing system. Please contact us for customized design, color(s), graduation(s), labeling and packaging.

To request samples or pricing or for additional information, call 1-941-360-0029 or email us at sales@asepsismedical.com
*not available in all territories

©Copyright 2017 by Asepsis Medical Technologies, LLC. Sarasota, FL.
All Rights Reserved, including the right of reproduction in whole or in part in any form

Dose-2-Weight Syringe® is a registered trademark of Asepsis Medical Technologies, LLC., and covered by one or more patents

including U.S. Patent 9,192,723 , U.S. Patent 9,302,050 ,  U.S. Patent 9750883 and Patents Pending

INFANTS ACETAMINOPHEN

Current Dosing Schedule 1
Acetaminophen 160 mg/5mL
lb mL mg mg/lb
lb Current Current Current
6 1.25 40 6.67
7 1.25 40 5.71
8 1.25 40 5.00
9 1.25 40 4.44
10 1.25 40 4.00
11 1.25 40 3.64
12 2.5 80 6.67
13 2.5 80 6.15
14 2.5 80 5.71
15 2.5 80 5.33
16 2.5 80 5.00
17 2.5 80 4.71
18 3.75 120 6.67
19 3.75 120 6.32
20 3.75 120 6.00
21 3.75 120 5.71
22 3.75 120 5.45
23 3.75 120 5.22
24 5.0 160 6.67
25 5.0 160 6.40
26 5.0 160 6.15
27 5.0 160 5.93
28 5.0 160 5.71
29 5.0 160 5.52
30 5.0 160 5.33
31 5.0 160 5.16
32 5.0 160 5.00
33 5.0 160 4.85
34 5.0 160 4.71
35 5.0 160 4.57
Average: 5.48
Dose-2-Weight Schedule 2,3,4,5
Acetaminophen 160 mg/5mL
lb mL mg mg/lb
lb D2W D2W D2W
6 0.86 27.6 4.60
7 1.01 32.2 4.60
8 1.15 36.8 4.60
9 1.29 41.4 4.60
10 1.44 46.0 4.60
11 1.58 50.6 4.60
12 1.73 55.2 4.60
13 1.87 59.8 4.60
14 2.01 64.4 4.60
15 2.16 69.0 4.60
16 2.30 73.6 4.60
17 2.44 78.2 4.60
18 2.59 82.8 4.60
19 2.73 87.4 4.60
20 2.88 92.0 4.60
21 3.02 96.6 4.60
22 3.16 101.2 4.60
23 3.31 105.8 4.60
24 3.45 110.4 4.60
25 3.59 115.0 4.60
26 3.74 119.6 4.60
27 3.88 124.2 4.60
28 4.03 128.8 4.60
29 4.17 133.4 4.60
30 4.31 138.0 4.60
31 4.46 142.6 4.60
32 4.60 147.2 4.60
33 4.74 151.8 4.60
34 4.89 156.4 4.60
35 5.03 161.0 4.60
Average: 4.60

1] Tylenol® Infants and Children’s Dosing Information for Healthcare Professionals

2] Adjusted for U.S. Market and mL dosing conformity – (adjusted from Dose-2-Weight Optimal Dose of 5.67 mg/lb. to 4.60 mg/lb.)     

3] US Food and Drug Administration – Over the counter Acetaminophen –Containing Drug Products in Children Background Package – Efficacy and Safety Studies published and reviewed at 4.53 mg/lb. to 6.80 mg/lb. Publish Studies mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

4] Boston University Fever Study –- Dosing at 4.53 mg/lb. to 6.80 mg/lb. Publish Studies mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

5] American Academy of Pediatric Endorses Weight Based Dosing – Recommended Dosing at 4.53 mg/lb. to 6.80 mg/lb. mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

   CHILDRENS ACETAMINOPHEN

Today’s Dosing Schedule 1
Acetaminophen 160 mg/5mL
 lb mL mg mg/lb
lb Current Current Current
 36  7.5 240 6.67
37 7.5 240 6.49
38 7.5 240 6.32
39 7.5 240 6.15
40 7.5 240 6.00
41 7.5 240 5.85
42 7.5 240 5.71
43 7.5 240 5.58
44 7.5 240 5.45
45 7.5 240 5.33
46 7.5 240 5.22
47 7.5 240 5.11
48 10 320 6.67
49 10 320 6.53
50 10 320 6.40
51 10 320 6.27
52 10 320 6.15
53 10 320 6.04
54 10 320 5.93
55 10 320 5.82
56 10 320 5.71
57 10 320 5.61
58 10 320 5.52
59 10 320 5.42
Average: 5.92
Dose-2-Weight Schedule 2,3,4
Acetaminophen 160 mg/5mL
lb mL mg mg/lb
lb D2W D2W D2W
36 6.33 202.7 5.63
37 6.51 208.3 5.63
38 6.69 213.9 5.63
39 6.86 219.6 5.63
40 7.04 225.2 5.63
41 7.21 230.8 5.63
42 7.39 236.5 5.63
43 7.57 242.1 5.63
44 7.74 247.7 5.63
45 7.92 253.4 5.63
46 8.09 259.0 5.63
47 8.27 264.6 5.63
48 8.45 270.2 5.63
49 8.62 275.9 5.63
50 8.80 281.5 5.63
51 8.97 287.1 5.63
52 9.15 292.8 5.63
53 9.32 298.4 5.63
54 9.50 304.0 5.63
55 9.68 309.7 5.63
56 9.85 315.3 5.63
57 10.03 320.9 5.63
58 10.20 326.5 5.63
59 10.38 332.2 5.63
Average: 5.63

1] Tylenol® Infants and Children’s Dosing Information for Healthcare Professionals

2] Adjusted for U.S. Market and mL dosing conformity – (adjusted from Dose-2-Weight Optimal Dose of 5.67 mg/lb. to 5.63 mg/lb.)     

3] US Food and Drug Administration – Over the counter Acetaminophen –Containing Drug Products in Children Background Package – Efficacy and Safety Studies published and reviewed at 4.53 mg/lb. to 6.80 mg/lb. Publish Studies mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

4] Boston University Fever Study –- Dosing at 4.53 mg/lb. to 6.80 mg/lb. Publish Studies mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.

5] American Academy of Pediatric Endorses Weight Based Dosing – Recommended Dosing at 4.53 mg/lb. to 6.80 mg/lb. mid-point and Dose-2-Weight Optimal Recommended Dose 5.67 mg/lb.